Our bodies produce natural cannabinoids that binds to the cannabinoid receptors, CB1 and CB2, which are also targeted by ingredients in marijuana. The two known endogenous cannabinoids, AEA (N-arachidonoylethanolamine) and 2-AG (2-arachidonoylglycerol), affects our mood, appetite, pain sensation, inflammation response, and memory. Thus, they have caught the attention of the pharmaceutical industry, which is trying to find ways of regulating AEA and 2-AG activities in order to treat mood disorders, obesity, and chronic pain.
In order to effectively control AEA and 2-AG, it's essential to understand how each of them function in the body. Although it's tricky to separate their individual roles, it does help that each of them is controlled by different enzymes. The enzyme FAAH hydrolyzes AEA to decrease its levels in the nervous system and periphery, while MAGL hydrolyzes 2-AG to reduce its activity.
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